Spine Regenerative Medicine

The Spine Heals on Its Own Terms. We've Learned How to Listen.

Helping athletes, active professionals, and everyday patients reduce pain and restore movement through precision regenerative medicine.

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Regenerative Medicine Trusted by Professional Sports

Our physicians serve as team doctors for professional sports organizations across the Midwest.

Professional sports team logos including AC St. Louis, Bandits, CBC, Gateway Otters, St. Louis, Marquette, and MIS

You've Been Told Your Spine Is "Degenerating"

That word - "degenerating" - sits heavy. It sounds inevitable. Final. But the narrative you've heard may be incomplete. Your intervertebral discs have lost hydration. Your facet joints show osteophytes on the MRI. But "degeneration" describes imaging findings, not biological destiny.

Your spine contains cells, growth factors, and inherent repair mechanisms that conventional medicine often overlooks. The disc doesn't want to herniate. The joint doesn't want to develop arthritis. These structures decompensate when load is mismanaged, when stabilizing muscles atrophy, when inflammatory cascades tip too far. Regenerative medicine resets those conditions. We don't fight your anatomy. We work with it.

What We Treat

Spinal Conditions We Treat with Regenerative Medicine

Each condition responds to a precise regenerative approach. No two spines are identical-neither are our protocols.

Degenerative Disc Disease

Progressive loss of disc height and hydration that causes chronic pain, stiffness, and reduced mobility as the spine loses its natural cushioning.

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Disc Bulge & Herniation

Nuclear material extends beyond the annulus, compressing nearby nerves and producing radiating pain, numbness, or weakness in the extremities.

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Annular Tears

Micro-injuries to the disc's outer fiber layers that cause deep, localized back pain-often missed on standard imaging but highly responsive to treatment.

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Pars Stress Reaction

A stress fracture of the pars interarticularis, common in young athletes and those with repetitive extension loading of the lumbar spine.

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Chronic Sprains & Strains

Persistent soft tissue injury with ongoing inflammation that disrupts daily function, often cycling between flare-ups and incomplete recovery.

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Spinal Arthritis & Facet Arthropathy

Osteoarthritic changes in the posterior spinal joints that produce stiffness, aching, and reduced range of motion-especially with extension and rotation.

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Neuralgia & Neuropathic Pain

Nerve-mediated pain from adhesions, entrapment, or chronic irritation that produces burning, shooting, or electric sensations along nerve pathways.

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Sacroiliac Joint Dysfunction

Instability or inflammation of the sacroiliac joint causing deep, one-sided low back and buttock pain that worsens with prolonged sitting or transitions.

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Piriformis Syndrome

Compression of the sciatic nerve by the piriformis muscle, producing buttock pain and sciatica-like symptoms that mimic lumbar disc pathology.

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High Hamstring Syndrome

Chronic tendinopathy at the ischial attachment causing deep seat pain and activity limitation-common in runners and those who sit for long periods.

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Spinal Stenosis

Narrowing of the spinal canal or neural foramina that compresses the spinal cord or nerve roots, often causing leg pain with walking.

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Costovertebral Rib Pain

Inflammation at the rib-vertebral junction causing sharp, localized thoracic pain that worsens with breathing, twisting, or sustained postures.

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How We Treat

Regenerative Therapies & Clinical Services

Every modality serves a specific biological purpose. We match the therapy to the tissue, not the other way around.

Exosome Therapy & Research

Cell-derived signaling vesicles that carry microRNA and bioactive molecules capable of modulating inflammation and activating repair at the molecular level. An emerging frontier in regenerative spine medicine.

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Regenerative Cellular Therapy

Adult regenerative cells are introduced into injured or degenerated areas to shift the local biology from breakdown to repair-modulating inflammation, signaling new cell growth, and restoring tissue architecture.

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Platelet-Rich Plasma (PRP) Therapy

A concentrated preparation of your own platelets, delivered directly to damaged tissue. The growth factors inside trigger a repair cascade that rebuilds what wear, strain, or injury has broken down.

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Prolotherapy (Proliferant Therapy)

A controlled micro-irritation that wakes up dormant healing. By introducing a simple dextrose solution into lax or injured connective tissue, we provoke the body into reinforcing structures it stopped repairing on its own.

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BMAC Stem Cell Therapy

Your bone marrow contains mesenchymal stem cells with the capacity to differentiate into cartilage, bone, and connective tissue. We harvest, concentrate, and deliver them precisely where regeneration is needed most.

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Ultrasound-Guided Injections

Real-time imaging allows us to watch the needle reach its target. No guesswork, no blind placement-every injection is confirmed visually, ensuring the therapeutic substance arrives exactly where it belongs.

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Diagnostic Ultrasound

A dynamic, radiation-free window into your musculoskeletal system. We assess tendons, ligaments, nerves, and joints in motion-catching pathology that static imaging like MRI can miss.

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Nerve Hydrodissection

Trapped nerves create pain that doesn't respond to rest or medication. Using ultrasound guidance, we introduce fluid around the compressed nerve to gently separate it from the surrounding tissue and restore glide.

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Interventional Pain Management

Targeted procedures that locate and address the anatomical source of chronic pain. We diagnose and intervene at the structure level-not to mask symptoms, but to change the underlying condition.

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Sports Medicine

From field-side triage to long-term performance recovery, we treat the full spectrum of athletic injury. Our approach combines regenerative biology with the demands of returning to competition safely and completely.

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Physical Rehabilitation

Regenerative injections lay the foundation-rehabilitation builds on it. Structured programs designed to retrain stability, restore range of motion, and protect the gains your biology has made.

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Concussion Treatment

Brain injuries require specialized evaluation and a recovery timeline that respects neurology. Our team includes physicians board-certified in brain injury medicine who guide patients from acute assessment through full return to activity.

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Our Approach

Identify the Structure,
Target the Source

I don't treat back pain. I identify the specific structure generating that pain. Is it the disc nucleus losing hydration? The annular fibers microtearing? The synovial joint inflaming? Once we know the anatomy, we select the regenerative modalities that address it.

PRP concentrates your own healing cells at the injury site. Prolotherapy stimulates fibrocyte proliferation in ligaments. BMAC harnesses the reparative capacity of bone marrow. Exosome therapy represents the frontier-cellular signaling molecules that modulate inflammation at the molecular level.

David Crane, MD
Meet Your Physician

David Crane, MD

Dr. Crane founded Crane Clinic Sports Medicine in 2005 and Bluetail Medical Group in 2008. He holds fellowship training in both Primary Care Sports Medicine and Emergency Medicine, with board certifications in both specialties.

His patients include high-level athletes and individuals who want to heal and restore normal function. He teaches regenerative medicine internationally and remains active in exosome research.

Learn more about Dr. Crane
20+
Years Clinical Experience
Board Certified-Sports & Emergency Medicine
Intl.
Physician Educator
Active
Exosome Research
Our Locations

Missouri, Wisconsin, and Indiana

Chesterfield, MO

St. Louis Metro

Columbia, MO

Central Missouri

Green Bay, WI

Northeast Wisconsin

Indianapolis, IN

Central Indiana

Your Spine Doesn't Have to
Define Your Story

Schedule a consultation to discuss your specific condition and whether regenerative medicine is right for you.